The Global Market for Ion Channel Modulators is Projected to Decline to US$7.3 Billion by 2022

Generic Incursion Ushers in New Challenges to Growth in the Global Ion Channel Modulators Market, According to a New Report by Global Industry Analysts, Inc.

GIA launches comprehensive analysis of industry trends, growth drivers, market size, and demand forecasts on the global Ion Channel Modulators market. The global market for Ion Channel Modulators is projected to decline to US$7.3 billion by 2022, weighed down by patent expirations, generic drug onslaught and lack of promising drugs in pipeline.

Lack of clear understanding of the structure and function of ion channels, perpetrated by their physiological, functional, and structural diversity has stifled research advances in the area of ion channel modulators. Most first generation ion channel modulator drugs lack subtype selectivity or specificity, and are plagued with side effects and restricted therapeutic indices, mandating research and development of next generation drugs with better safety profile, higher specificity and superior efficacy. Complexity in the functionality of ion channels and diversity they entail mandate continued research in understanding their structure and function, and persevere to develop efficacious drugs. Despite the valuable genetic information provided by the Human Genome Project related to ion channels and their use as drug targets, research in this pace is sluggish resulting in a weak pipeline of products. Issues with target validation regarding drug action, however, pose hurdles to the development of more effective drugs. Compounding these issues is the string of patent expirations in recent years as well as the genericization of the market. With the leading ion channel modulators losing market exclusivity in recent years and a few more scheduled to lose patent protection in the foreseeable future, the market is witnessing revenue erosion and gradually ceding share to generic formulations.

Ion channels refer to a class of unique and complex proteins that control the transport of charged particles (ions) across cell membranes to regulate a wide range of physiological processes. Cellular functions, such as ion flow, cell volume regulation and control of membrane potential, hence are dependent on these ion channels directly involving them in pathophysiology of various maladies. Ion channel modulators are used in the treatment of a wide array of clinical conditions, such as hypertension, convulsions, pain, diabetes, and tobacco dependence. Among these, the calcium channel inhibitors addressing high blood pressure represent one of the widely used ion channel modulation drugs currently. Sodium channel blockers, potassium channel blockers and potassium channel openers are some of the other leading drug categories. Voltage-gated sodium channels as well as calcium channels are the targets of most current pain medications, such as gabapentin, as well as the drugs under development. Further potential for novel ion channel modulators is immense with the approach carrying huge potential to alter treatment paradigm of a wide range of channelopathies, given aging population worldwide, increase in incidence and prevalence of various targeted diseases particularly cardiovascular diseases and CNS diseases, and increasing awareness and healthcare expenditure.

As stated by the new market research report on Ion Channel Modulators, the U.S. represents the largest market worldwide. Increasing prevalence of various conditions targeted by ion channel modulators, growing adoption of these drugs and patent protection for some leading drugs lead to higher revenues of ion channel modulators in the market. However, Asia-Pacific represents the fastest growing market worldwide, with a CAGR of 1.8% through the analysis period. Growing prevalence of targeted conditions in China and India, increasing awareness, better access to healthcare and an already established generic base are expected to buoy market growth in the region.

Major players in the market include Allergan plc, AstraZeneca, Bayer HealthCare Pharmaceuticals, Biogen Inc., GlaxoSmithKline Plc., H. Lundbeck A/S, Johnson & Johnson, Novartis AG, Parion Sciences Inc., Pfizer Inc. and Sanofi S.A. among others.

The research report titled “Ion Channel Modulators: A Global Strategic Business Report” announced by Global Industry Analysts Inc., provides a comprehensive review of market trends, issues, drivers, mergers, acquisitions and other strategic industry activities of global companies. The report provides market estimates and projections for Ion Channel Modulators in value terms for all major geographic markets such as United States, Canada, Japan, Europe (France, Germany, Italy, UK, Spain, Russia and Rest of Europe), Asia-Pacific and Rest of World.


For enquiries e-mail us at rsd@strategyr.com or info411@strategyr.com

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Global Industry Analysts, Inc. 6150 Hellyer Ave., San Jose CA 95138, USA, All Rights Reserved.

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