Healthcare Reforms Aimed at Preventing Genetic Disorders from Being Passed On to Future Generations Drives the Importance of Prenatal Diagnostics in Maternal Healthcare


The global market for Prenatal Diagnostics is projected to reach US$6.8 billion by 2022, driven by delayed pregnancies, rising incidence of chromosomal anomalies in the fetus causing Down’s syndrome and other disorders, and technological improvements that minimize false negatives and enhance accuracy in results.

Prenatal testing involves screening and diagnostic methods carried out during pregnancy for various purposes, such as determination of fetal sex and identification of potential genetic and chromosomal abnormalities of the fetus. cff-DNA refers to cell-free fetal DNA, which escapes into the maternal blood circulation via the placenta, and offers crucial information about the fetal genetic makeup and links to any potential disease. Non-Invasive Prenatal Testing (NIPT) technique analyzes cff-DNA in the maternal blood sample to detect chromosomal aneuploidies, especially trisomy of the chromosome 21, which is commonly called Down’s syndrome. NIPT is more accurate than serum screening or ultrasonography and avoids the discomfort and risk of invasive testing.  

The global prenatal diagnostics market is benefiting from the high risk of chromosomal abnormalities associated with increasing maternal age, especially across the developed nations where delayed pregnancy is a common occurrence. Even among the emerging economies of the developing world, increasing healthcare expenditure, and shifting of childbearing preferences to a later maternal age are driving growth of prenatal diagnostics. Increased incidences of Down’s syndrome, Patau syndrome, Edwards syndrome (trisomies of chromosomes 21, 13 & 18 respectively), and Turner syndrome (monosomy x), favors growth in the market. Furthermore, technological improvements that facilitate elimination or reduction of false negatives and enhance accuracy in results are expected to further boost the market. Technological advancements in genomics ensure accuracy of prenatal diagnostics. DNA sequencing is increasingly carried out via Next-Generation Sequencing (NGS) platforms. 

Massively Parallel Sequencing (MPS) is a method that entails breaking down a large sequencing project into smaller projects. Massively parallel sequencing of maternal plasma enables identification of chromosomal origin of each sequenced DNA molecule, fetal and maternal, and can detect chromosomal over-representation or trisomies in the fetus, or even under-representation. Sequenom’s MaterniT21™, Aria/Roche’s Harmony test, Illumina’s Verifi™, Natera’s Panorama™, and others including LifeCodexx’ PrenaTest® represent some of the leading prenatal diagnostic tests.

As stated by the new market research report on Prenatal Diagnostics, the United States represents the largest market worldwide. Asia-Pacific ranks as the fastest growing market, with a CAGR of 6.2% over the analysis period led by significant changes in birthing timeline among the expanding base of educated working women; better healthcare awareness; rising disposable income and increased ability to spend on high quality diagnostic care & services.  

Major players in the market include ANGLE Plc, Berry Genomics Co. Ltd., BGI Genomics, F. Hoffmann-La Roche Ltd., Hologic Inc., Illumina Inc., Laboratory Corporation of America® Holdings, Lifecodexx AG, Natera Inc., Quest Diagnostics Inc., Ravgen Inc., and Sequenom Inc., among others.

The research report titled "Prenatal Diagnostics - Market Analysis, Trends, and Forecasts" announced by Global Industry Analysts Inc., provides a comprehensive review of market trends, growth drivers, mergers and acquisitions, and other strategic industry activities of major companies worldwide. The report provides market estimates and projections for geographic markets, such as the US, Canada, Japan, Europe (France, Germany, Italy, UK, Spain, Russia, and Rest of Europe), Asia-Pacific (China, India, and Rest of Asia-Pacific), Latin America (Brazil, and Rest of Latin America), and Rest of World.  

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